PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

advances in targeted drug delivery

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From systemic shotgun to site-specific nanoparticle-targeted delivery: a new paradigm for drug delivery.

Since the introduction of percutaneous techniques for the relief of symptomatic obstructive atherosclerotic coronary artery disease in the late 1970s, the major Achilles heel was restenosis. After nearly 3 decades of study, the cellular and molecular biology of this complex response to injury is now far better understood and includes the role of thrombosis, cellular proliferation, inflammation,...

Cancer immunotherapy trials: leading a paradigm shift in drug development

Background Cancer immunotherapy has a long history in the clinic. William Coley was an orthopedic surgeon in the late 1800’s who noted marked tumor regression in a patient with severe erysipelas. Based on this observation, he hypothesized that stimulating the immune system could effectively treat cancer. Thus, over the next decades he gave various bacterial products, including live bacteria, to...